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Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of treatment resistant major depression

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QUESTION

Question:

What is the clinical efficacy of high frequency repetitive transcranial magnetic stimulation in people with treatment resistant depression?

Outcomes:

The primary outcome was clinical response defined using a global rating scale (eg, “much improved” or “very much improved” on the Clinical Global Impression Scale (CGI)) or a set level of improvement on a continuous depression rating scale (eg, improvement of 50% or greater from baseline to end of treatment on the Hamilton Depression Rating Scale (HAMD) or the Montgomery–Asberg Depression Rating Scale (MADRS)). Secondary outcomes included depressive symptoms (end point symptom scores) and remission (defined as a score on a depression rating scale within the normal range—eg, HAMD score ⩽7, MADRS score ⩽12 or …

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