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Switching to aripiprazole from olanzapine leads to weight loss in overweight people with schizophrenia or schizoaffective disorder

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QUESTION

Question:

Does switching to aripiprazole from olanzapine improve metabolic status in overweight people with schizophrenia or schizoaffective disorder?

Patients:

Patients with schizophrenia or schizoaffective disorder (DSM-IV-TR) treated with olanzapine only (10–20 mg/day for 1–24 months). Inclusion criteria: body mass index ⩾27; Clinical Global Impressions-Severity score ⩽4. Main exclusion criteria: other axis I disorder; diabetes; neurological condition or mental retardation; suicide risk; alcohol or drug dependence or electroconvulsive therapy 3 months prior to study; previous failure to respond to aripiprazole; clinically significant ECG, blood result or vital sign; pregnant, breastfeeding or not reliably using contraception for the duration of the study plus 4 weeks after study completion.

Setting:

Multinational (countries not stated); recruitment 30 March 2004 to 8 August 2006.

Intervention:

Switch to aripiprazole (n = 88) or continued olanzapine (n = 85) for 16 weeks. Switch participants received up to 15 mg/day aripiprazole across 2 weeks while decreasing olanzapine dose to nil, then 15 mg/day (fixed for 4 weeks) and then flexible dose …

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