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Dimebon improves cognitive function in people with mild to moderate Alzheimer’s disease

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QUESTION

Question:

Does dimebon improve cognitive function in people with mild to moderate Alzheimer’s disease?

Patients:

183 people over 50 years of age with Alzheimer’s disease (DSM-IV and National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders criteria); Mini-Mental State Examination (MMSE) score 10–24; modified Hachinski ischaemic score ⩽4; and CT/MRI scan consistent with Alzheimer’s within 12 months prior to enrolment. Main exclusion criteria: potential other cause of dementia (eg, thyroid disease); cholinesterase inhibitor or N-methyl-D-aspartate receptor antagonist use within 60 days prior to enrolment; schizophrenia; stroke; Parkinson’s disease; seizure disorder; unstable medical illness; or hepatic/renal disease.

Setting:

11 sites in Russia; recruitment September 2005–February 2006.

Intervention:

Dimebon (10 mg three times a day for 7 days, increased to 20 mg three times a day for the remainder of the study) or placebo for 26 weeks. Blinded treatment could be continued for an additional 26 week extension period if the participant agreed.

Outcomes:

Primary …

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