Article Text

PDF
Atypical antipsychotics fail to improve functioning or quality of life in people with Alzheimer’s disease

Statistics from Altmetric.com

QUESTION

Question:

What are the clinical responses to atypical antipsychotic drugs in people with Alzheimer’s disease?

Patients:

421 people (mean age 78 years, 56% female) with either dementia of the Alzheimer’s type (DSM-IV) or probable Alzheimer’s disease (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s Disease and Related Disorders Association Criteria) and psychosis or agitated/aggressive behaviour. (See online notes for list of inclusion and exclusion criteria.)

Setting:

Outpatient setting, 42 centres, USA; time period not stated.

Intervention:

Flexibly dosed olanzapine, quetiapine, risperidone or placebo (randomisation in a 2:2:2:3 ratio) for up to 36 weeks.

Outcomes:

Psychiatric and behavioural symptoms measured at baseline and 2, 4, 8, 12, 24 and 36 weeks using: Neuropsychiatric Inventory (NPI); Brief Psychiatric Rating Scale (BPRS); Cornell Scale for Depression Dementia; and Alzheimer’s Disease Cooperative Study Clinical Global Impression of Change (CGIC). Cognitive skills, functional abilities, care needs and quality of life were measured at baseline and at 12, 24 …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.