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Use of antidepressants in pregnancy does not increase risk of postpartum haemorrhage

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QUESTION

Question:

Do selective serotonin reuptake inhibitors (SSRIs) and other antidepressants increase risk of postpartum haemorrhage if taken in late pregnancy?

People:

28 863 Canadian women aged 16–45 years who received government-funded prescription cover for drugs in the 2 years prior to the delivery of their baby identified through the Ontario Drug Benefit (ODB) database. Cases (n = 2460) were women in this cohort with a diagnosis of postpartum haemorrhage following a vaginal or caesarean delivery (as reflected in the Canadian Institute for Health Information Discharge Abstract Database); if haemorrhage occurred in more than one pregnancy, only the first was included. Exclusions: several medical conditions including alcoholism, liver disease, thrombosis, malignant neoplasia, pulmonary embolism, platelet defects, and hereditary bleeding disorders and exposure to particular drugs (antipsychotics, anticonvulsants, anticoagulants, monoamine oxidase inhibitors, more than one antidepressant, mood stabilisers, antiplatelets and systemic corticosteroids). Control women (26 403; up to 10 for each case) were …

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