Article Text

PDF
Little difference between haloperidol, risperidone and olanzapine in weight gain after 1 year of treatment

Statistics from Altmetric.com

QUESTION

Question:

What effects do haloperidol, risperidone and olanzapine have on weight gain in drug-naive psychotic patients after 1 year?

Patients:

164 drug-naive first episode psychotic patients (15 to 60 years old; mean age 27 years, mean body mass index (BMI) 23.1 kg/m2) with DSM IV brief psychotic disorder, schizophreniform disorder, schizophrenia or schizoaffective disorder who were consecutively referred to several psychiatric units in Spain. Exclusion criteria: drug dependence, mental retardation, serious medical comorbidity.

Setting:

Outpatient and inpatient psychiatric units of one university hospital, Cantabria, Spain; February 2001 to February 2005.

Intervention:

Haloperidol (3–9 mg/day), olanzapine (5–20 mg/day) or risperidone (3–6 mg/day) for 12 months. Patients were switched to a different antipsychotic if they did not respond to 6 weeks of treatment or if they had significant side effects.

Outcomes:

Change in body weight and BMI. Measurements taken at 12 weeks and 1 year follow-up. Analyses were adjusted for baseline BMI, age and sex.

Patient follow-up:

90% completed 3 months’ …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.