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Tranquilising agitated mentally ill patients: intramuscular haloperidol plus promethazine reduces need for additional medication or medical attention compared to olanzapine

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P Tharyan

Correspondence to: P Tharyan, Department of Psychiatry, Christian Medical College, Vellore and BV Moses Centre for Clinical Trials and Evidence Based Medicine, Christian Medical College, Vellore 632002, Tamil Nadu, India; prathap@cmcvellore.ac.in

QUESTION

Question:

Intramuscular haloperidol plus promethazine or intramuscular olanzapine: which is more effective for the emergency treatment of agitated and violent adults with mental illness?

Patients:

300 hospitalised adults with mental illness (ICD-10 classified), presenting with aggressive or violent behaviour. Inclusions: consecutive patients in the psychiatric unit for whom intramuscular sedation was indicated and where intervention did not put the patient at risk.

Setting:

Psychiatric unit of the Christian Medical College, Vellore, South India; September 2005 to July 2006.

Intervention:

Single intramuscular injection …

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