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Metformin and lifestyle changes reduce antipsychotic-related weight gain in adults with schizophrenia

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Jing-Ping Zhao

Correspondence to: Jing-Ping Zhao, Mental Health Institute of the Second Xiangya Hospital, Central South University, 410011, 139 Renmin Middle Road, Changsha, Hunan, China; werenrong2005@yahoo.com.cn

QUESTION

Question:

How effective are a lifestyle intervention and metformin—alone and in combination—at reducing antipsychotic-induced weight gain in adults?

Patients:

128 people aged 18–45 years with a first psychotic episode of schizophrenia (according to DSM-IV). Inclusions: weight gain of more than 10% of their pre-drug body weight within the first year of treatment with a targeted antipsychotic agent (clozapine, olanzapine, risperidone, or sulpiride), documented weight and treatment history, relatively stable improvement (PANSS ⩽60), taking only 1 antipsychotic at a stable dose (changed by <25% in the past 3 months), under care of parent or guardian who monitored food, exercise, medication intake. Exclusions: evidence of liver or renal dysfunction, cardiovascular disease, diabetes mellitus, substance abuse, psychiatric diagnosis other than schizophrenia, or other conditions that limited ability to perform lifestyle modifications.

Setting:

Outpatient clinic of the Mental Health Institute of the Second Xiangya Hospital at Central South University in China; recruitment October 2004 to December 2006. …

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