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Prognostic factors for progression to psychosis in high risk youth

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Tyrone D Cannon

Correspondence to: Tyrone D Cannon, PhD, Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Los Angeles, CA 90095, USA; cannon@psych.ucla.edu

QUESTION

Question:

How common is conversion to psychosis in high risk youths, what factors predict this risk?

Population:

370 people (mean age 18 years) with prodromal psychotic symptoms (according to Structured Interview for Prodromal Syndromes (SIPS) criteria) who had been referred by school counsellors or community-based mental health professionals. The main SIPS criteria include: onset or worsening in the preceding 12 months of attenuated positive thoughts in one or more of five categories (grandiosity, unusual thought, paranoia/suspicion, disorganised communication, or perceptual abnormalities; rated from 0 (none) to 6 (fully psychotic state), score of 3–5 indicates a prodromal state); onset in previous 3 months of brief intermittent psychotic symptoms not meeting DSM-IV threshold for psychotic disorder; or the combination of deterioration of ⩾30% on the General Assessment of Functioning Scale in the past 12 months plus a genetic risk factor (either schizotypal personality disorder or a first degree relative with psychotic disorder).

Setting:

Eight clinical research centres …

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