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Ongoing pharmacotherapy maintains quality of life benefits in older adults with major depression

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Charles F Reynolds III

Correspondence to: Charles F Reynolds III, MD, WPIC (E1135), 3811 O’Hara Street, Pittsburgh, PA 15213, USA; reynoldscf@upmc.edu

QUESTION

Question:

Does continuing treatment with combined paroxetine and interpersonal psychotherapy sustain health-related quality of life benefits?

Patients:

116 people aged 70 years and older who had been diagnosed with major depression, which had responded to treatment with paroxetine and interpersonal psychotherapy. Initially 195 older adults with non-psychotic DSM-IV major depression and 17-item Hamilton Rating Scale for Depression (HRSD-17) score ⩾15 and Mini-Mental State Examination score ⩾17 were recruited and treated with paroxetine and interpersonal psychotherapy. The 151 people who responded (3 consecutive weeks with HRSD-17 score ⩽10) continued to received open treatment for 16 weeks. The 116 people who did not relapse during this period entered the maintenance phase.

Setting:

University-based clinic for treatment of major depression in old age; recruitment March 1999 to February 2003.

Intervention:

Maintenance treatment with: paroxetine plus clinical management, paroxetine plus monthly interpersonal psychotherapy, placebo plus clinical management, or placebo …

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