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Feldman HH, Lane R. Rivastigmine: a placebo-controlled trial of BID and TID regimens in patients with Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2007 Mar 12; [Epub ahead of print].
Randomised controlled trial.
Twenty six weeks (treatment period only).
Thirty seven research centres, Australia, Canada, Ireland, Italy, South Africa, and the UK; time period not stated.
678 community dwelling adults aged ⩾50 years with Alzheimer’s disease (AD; meeting both DSM-IV criteria and criteria for “probable” Alzheimer’s disease of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer’s disease and Related Disorders Association), and who had a Mini-Mental State Examination score of 10–26. Exclusions: severe obstructive pulmonary disease, cardiac disease, or other life threatening condition; use of anticholinergic drugs, insulin, psychotropics (with some exceptions), supplements containing acetylcholine precursors, or supposed memory enhancers.
Dr Howard Feldman, S192–2211 Westbrook Mall, Division of Neurology, Department of Medicine, University of British Columbia Hospital, Vancouver, BC, Canada, V6T 2B5
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