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Thompson S, Herrmann N, Rapoport MJ, et al. Efficacy and safety of antidepressants for treatment of depression in Alzheimer’s disease: a meta-analysis. Can J Psychiatry 2007;52:248–55.
Systematic review with meta-analysis.
MEDLINE (January 1966 to June 2006), the Cochrane Database (search date not stated), and hand search of reference lists of relevant articles.
Study selection and analysis:
Double-blind placebo controlled trials of antidepressants in adults with Alzheimer’s disease (DSM-III, DSM-III-R, DSM-IV, or National Institute of Neurological and Communicative Diseases and Stroke-Alzheimer’s Disease and Related Disorders criteria) and depression (major depressive disorder or episode, dysthymic disorder, or minor depression according to DSM-III, DSM-III-R, or DSM-IV criteria). Only English language studies were included, and studies of drugs not available in North America or studies not presenting sufficient data for inclusion in meta-analysis were excluded. Study quality appraisal and data extraction were carried out by two researchers. Analyses were conducted using Review Manager Version 4.2. …
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