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Head injury slightly increases risk of non-affective psychosis but not schizophrenia

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 Q Does head injury increase risk of developing schizophrenia or non-affective psychosis?

METHODS

Embedded ImageDesign:

Case-control study.

Embedded ImageFollow-up period:

Nineteen years.

Embedded ImageSetting:

Sweden; 1973–2002.

Embedded ImagePeople:

748 people with ICD-9 or -10 schizophrenia (cases) and 14 960 matched controls; 1526 people with ICD-9 or -10 non-affective psychosis (cases) and 30 520 matched controls. Participants born between 1973 and 1980. Cases identified by hospital admissions for schizophrenia or non-affective psychosis between 1989 and 2002. Twenty age and sex matched controls without schizophrenia or non-affective psychosis were randomly selected for each case. Exclusion criteria: death, emigration, onset of schizophrenia or other non-affective psychosis before the age of 16, or incomplete data. Data obtained from the Swedish Medical Birth Registry, Population and Housing Census of 1990, Inpatient Discharge Register, Cause of Death Register and Emigration Register.

Embedded ImageRisk factors:

Hospital admission for head injury, before diagnosis of schizophrenia or non-affective psychosis. Analyses were adjusted for year location of birth, gestational age, birth weight …

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