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Q Do antidepressants increase the risk of self-harm or suicidal behaviour in children and adolescents?
Systematic review with meta-analysis.
UK Committee for Safety of Medicines (CSM) review up to January 2004; Medline and PsycINFO from January 2004 to August 2005; the Cochrane Database; the GlaxoSmithKline website for paroxetine, and contact with researchers in the field.
Study selection and analysis:
Randomised controlled trials (RCTs) in children and adolescents with a major depressive disorder comparing antidepressants versus placebo for 8–12 weeks.
Suicide-related events (attempted suicide, suicidal thoughts or self-harm from CSM data; or worsening suicide ideation or suicide attempt or both from Treatment for Adolescents with Depression Study).
Sixteen RCTs met inclusion criteria (n = 2741; 5 RCTs of fluoxetine, 3 RCTs of paroxetine, 2 RCTs each of sertaline, citalopram, venlafaxine and mirtazapine). Most of …
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