Statistics from Altmetric.com
Randomised controlled trial.
Double blind (fluoxetine and placebo), single blind (cognitive behavioural therapy (CBT) and combination treatment).
Twelve weeks (treatment period only).
US; enrolment 2000–3.
439 adolescents (12–17 years) with major depressive disorder (DSM-IV) and a Children’s Depression Rating Scale-Revised (CDRS-R) total score ⩾45, demonstrating impairment due to depression in at least two settings (home, school or with friends) for at least 6 weeks. Exclusions: comorbid conditions requiring medication, previously failed CBT or two trials of selective serotonin reuptake inhibitor, currently receiving psychotherapy or psychotropic medication.
Fluoxetine, CBT (15 sessions), fluoxetine plus CBT, or placebo for 12 weeks. Fluoxetine and placebo started at 10 mg/day, …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.