Article Text

PDF
No difference in depression relapse rates between maintenance electroconvulsive therapy and lithium plus nortriptyline

Statistics from Altmetric.com


 
 Q How effective are electroconvulsive therapy or lithium carbonate plus nortriptyline hydrochloride as maintenance treatments in major depression?

METHOD

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Unconcealed.

Embedded ImageBlinding:

Unblinded.

Embedded ImageFollow-up period:

Six months (treatment period only).

Embedded ImageSetting:

Five academic medical centres (outpatient psychiatry clinics) in the US; 1997–2004.

Embedded ImagePatients:

Phase 1 (acute non-randomised treatment): 531 people aged 18–85 years with primary DSM-IV major depression (24-item Hamilton Rating Scale for Depression (HRSD) total score ⩾21) referred for bilateral electroconvulsive therapy (ECT). Phase 2 (maintenance treatment): 201 people with remission in phase 1 (⩾60% decrease from baseline in HRSD total score and HRSD score ⩽10 on two consecutive ratings), an HRSD score ⩽10 or less for 1 week without psychotropic medication, and modified Mini-Mental State Examination (mMMSE) score ⩾21. Exclusion criteria: ECT in 3 months before phase 1, medical conditions contraindicating study treatments, substance dependence in last 12 months, or disorders affecting cognition.

Embedded ImageIntervention:

ECT (10 sessions: once weekly …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.