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Q How do second generation antipsychotics compare with haloperidol for the treatment of acute schizophrenia?
Randomised controlled trial.
Unblinded (treating physician and participant aware of the treatment). Assessors of the Brief Psychiatric Rating Scale and side effects were blinded; the unblinded treating physician made the decision about discharge.
At least 3 weeks.
Six hospital adult psychiatric inpatient units, USA; recruitment January 2004 to February 2005.
327 newly admitted adult inpatients (aged 18 years and over) with DSM-IV schizophrenia, schizoaffective disorder or schizophreniform disorder. Exclusions: substance-induced psychotic disorder, bipolar disorder, major depressive disorder, history of non-response to study drugs or response to non-study drugs, pregnancy or breastfeeding, or medical condition contraindicating study treatments.
Aripiprazole, haloperidol, olanzapine, quetiapine, risperidone or ziprasidone for at least 3 weeks (doses determined using manufacturer’s dose recommendations). Treatment could continue beyond …
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