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Q Are first and second generation antipsychotics equally effective and safe for people with first-episode non-affective psychosis?
Randomised controlled trial.
Six weeks (treatment period only).
One outpatient and one inpatient clinic at a university hospital, Cantabria, Spain; enrolment February 2001 to February 2005.
182 adults (15–60 years old; 93% antipsychotic naive) with non-affective psychotic disorder (DSM-IV) and psychotic symptoms of moderate severity or greater (Scale for the Assessment of Positive Symptoms). Exclusions: DSM-IV mental retardation, DSM-IV drug dependence, or ⩾6 weeks’ total lifetime adequate antipsychotic treatment.
Haloperidol (3–9 mg/day; mean modal dose 5.4 mg/day) risperidone (3–6 mg/day; mean modal dose 4 mg/day), or olanzapine (5–20 mg/day; mean modal dose 15.3 mg/day).
Response (⩾40% reduction in Brief Psychiatric Rating Scale score), adverse events including treatment-emergent parkinsonism (Simpson-Angus Scale >3) …
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