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Prospective cohort study.
European Schizophrenia Outpatient Health Outcomes study, Germany; recruitment January to December 2001.
2960 adult outpatients with DSM-IV schizophrenia either switching to or beginning a new antipsychotic (mean age 42 years; 49% male). Exclusions: IQ ⩽70, other DSM-IV schizophrenia spectrum disorders, bipolar I disorder, or psychotic disorder.
Baseline predictors: age; gender; illness duration; symptoms (Clinical Global Impressions-Severity of Illness (CGI)-Schizophrenia scale overall severity score subscale scores). Functional predictors included occupational status, independent living and subjective wellbeing (Subjective Wellbeing Under Neuroleptic Treatment Scale (SWN-K)). Antipsychotic treatment factors included first antipsychotic, neurological side effects, and atypical or typical initial antipsychotic medication. Early treatment predictors were: symptomatic remission, functional remission (being employed, active student, household head, and living independently) and adequate subjective wellbeing (SWN-K score …
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