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Bipolar I disorder is common in first-degree relatives of children with prepubertal and early adolescent bipolar I disorder

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Q How common is bipolar I disorder in relatives of children with prepubertal and early adolescent bipolar disorder?

METHODS

Embedded ImageDesign:

Cross-sectional study.

Embedded ImageSetting:

St Louis, USA; interviews conducted September 1999 to April 2004.

Embedded ImagePopulation:

690 first-degree relatives (age ⩾6 years) of 219 children (probands) with prepubertal and early adolescent bipolar I disorder (PEA-BP-I; 95 children with DSM-IV criteria for mania with ⩾1 cardinal mania symptom; 284 relatives), DSM-IV attention deficit/hyperactivity disorder (ADHD; 47 children, 143 relatives) or healthy matched controls (77 children matched to PEA-BP-I group for age, gender, ethnicity, socioeconomic status and area of residence; 263 relatives). No exclusion criteria were given for first degree relatives. Exclusions for probands: poor physical health; bipolar I disorder <2 weeks (PEA-BP-I probands only); lifetime or …

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