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Q How common is bipolar I disorder in relatives of children with prepubertal and early adolescent bipolar disorder?
St Louis, USA; interviews conducted September 1999 to April 2004.
690 first-degree relatives (age ⩾6 years) of 219 children (probands) with prepubertal and early adolescent bipolar I disorder (PEA-BP-I; 95 children with DSM-IV criteria for mania with ⩾1 cardinal mania symptom; 284 relatives), DSM-IV attention deficit/hyperactivity disorder (ADHD; 47 children, 143 relatives) or healthy matched controls (77 children matched to PEA-BP-I group for age, gender, ethnicity, socioeconomic status and area of residence; 263 relatives). No exclusion criteria were given for first degree relatives. Exclusions for probands: poor physical health; bipolar I disorder <2 weeks (PEA-BP-I probands only); lifetime or current major depressive disorder or bipolar disorder (ADHD and healthy probands only); lifetime or current ADHD (healthy probands only); IQ<70; other major medical or neurological disorder; pregnant; substance abuse; schizophrenia; …
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