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Q Does cannabis use increase the likelihood that a person will develop mania?
Prospective cohort study.
General population in 90 randomly selected municipalities, the Netherlands; time period not stated.
4815 people aged 18–64 years (mean age 41.2 years, 53% female) selected using multistage stratified random sampling of private households. Exclusions not stated.
Trained interviewers used the Composite International Diagnostic Interview (CIDI) at baseline, 1 and 3 years to assess lifetime use and highest frequency of use of cannabis. Mania and psychosis were also assessed. Psychosis was classified as at least 1 positive rating (score of 2 to 6) on any of the 17 CIDI core psychosis items. Logistic regression was used to calculate odds ratios and 95% confidence intervals. Analyses were adjusted for age, sex, ethnicity, educational level, marital status, neuroticism, lifetime other …
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