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Q Is oxcarbazepine safe and effective for the treatment of children and adolescents with bipolar disorder?
Randomised controlled trial.
Twenty outpatient centres, USA; time period not stated.
116 child and adolescent outpatients (aged 7–18 years) with DSM-IV bipolar I disorder (confirmed by Schedule for Affective Disorders and Schizophrenia for School Age Children – Present and Lifetime Version), and experiencing a manic or mixed episode (baseline score ⩾ 20 on the Young Mania Rating Scale (YMRS)). Exclusions: current primary DSM-IV schizophrenia, delirium, substance induced mood disorder, anorexia, bulimia, or autism; need for psychiatric hospitalisation; previous seizure disorder; IQ <70; suicidal; homicidal; or previous non-response or hypersensitivity to oxcarbazepine.
Oxcarbazepine or placebo for 7 weeks. Oxcarbazepine treatment was …
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