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Oxcarbazepine is no more effective than placebo for reducing manic symptoms of bipolar I disorder in children and adolescents

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Q Is oxcarbazepine safe and effective for the treatment of children and adolescents with bipolar disorder?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Unclear.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow-up period:

Seven weeks.

Embedded ImageSetting:

Twenty outpatient centres, USA; time period not stated.

Embedded ImagePatients:

116 child and adolescent outpatients (aged 7–18 years) with DSM-IV bipolar I disorder (confirmed by Schedule for Affective Disorders and Schizophrenia for School Age Children – Present and Lifetime Version), and experiencing a manic or mixed episode (baseline score ⩾ 20 on the Young Mania Rating Scale (YMRS)). Exclusions: current primary DSM-IV schizophrenia, delirium, substance induced mood disorder, anorexia, bulimia, or autism; …

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