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Q Is clozapine more effective than other second-generation antipsychotics for people with resistant schizophrenia?
Randomised controlled trial.
Single blind (assessors blinded).
Five centres, UK; time period not stated.
136 adults (18–65 years old) with DSM-IV schizophrenia, schizoaffective or delusional disorder and poor clinical response to at least two other treatments. Exclusions: neuroleptic malignant disorder, substance misuse or medical disorder responsible for psychotic symptoms.
Clozapine (end dose range 100–600 mg/day; mean end dose 333 mg/day) or other second-generation antipsychotic (amisulpride 600–800 mg/day (mean 683 mg/day), olanzapine 10–30 mg/day (mean 19 mg/day), quetiapine 300–750 mg/day (mean 520 mg/day), or risperidone 3–8 mg/day (mean 6 mg/day)). Selection of second-generation antipsychotic made by clinicians based on best …
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