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Brief cognitive-behavioural therapy reduces hospital readmission but does not reduce overall symptoms of schizophrenia

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 Q Is brief cognitive-behavioural therapy effective for people with schizophrenia?

METHODS

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Concealed.

Embedded ImageBlinding:

Single blind (assessors blinded).

Embedded ImageFollow-up period:

One year.

Embedded ImageSetting:

Six healthcare sites, UK; time period not stated.

Embedded ImagePatients:

422 people with schizophrenia (ICD-10). Most participants had ongoing symptoms or were at risk of relapse. Exclusions: currently experiencing schizophrenia relapse, primary diagnosis of alcohol or substance abuse, organic brain disease, or learning disability.

Embedded ImageIntervention

Brief cognitive-behavioural therapy (CBT: 6 technique-based sessions over 2–3 months given by trained mental health nurses—including techniques for managing positive and negative symptoms and improving medication compliance) or usual care.

Embedded ImageOutcomes:

Primary outcomes: overall symptoms (Comprehensive Psychopathological Rating Scale (CPRS)); insight (Insight Rating Scale (IRS)); depression (Montgomery-Asberg Depression Rating Scale (MADRS)). Secondary outcomes: positive symptoms (Psychotic Symptom Rating Scales (PSYRATS)); negative symptoms …

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