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Q Does reducing plasma homocysteine concentration result in improved cognitive function in older adults?
Randomised controlled trial.
Follow up period:
Dunedin, New Zealand; August 2002 to December 2004.
276 adults aged 65 years and older with a fasting homocysteine concentration ⩾13 μmol/l and normal plasma creatinine (⩽115 μmol/l in women and ⩽133 μmol/l in men). Main exclusions: suspected dementia; medications that interfere with folate metabolism; vitamin supplementation; treatment for depression.
Daily oral vitamin B supplement (1000 μg folate, 500 μg vitamin B12, 10 mg vitamin B6) or placebo.
Cognitive function (individual scores and combined effect size for: Mini-Mental State Examination, Weschler Paragraph Recall Test, Category Word Fluency Test, Rey Auditory Verbal Learning Tests (trials I-V and VII), Raven’s Progressive Matrices, Controlled Oral Word Association Test, and …
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