Article Text

Pregabalin and venlafaxine improve symptoms of generalised anxiety disorder

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 Q Does pregabalin or venlafaxine treatment reduce symptoms of generalised anxiety disorder compared with placebo?


Embedded ImageDesign:

Multicentre randomised controlled trial.

Embedded ImageAllocation:


Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Six weeks (treatment period only).

Embedded ImageSetting:

Seventy six centres (52 primary care centres and 24 psychiatric centres) in five European countries, 1999–2001.

Embedded ImagePatients:

426 adults with DSM-IV generalised anxiety disorder (GAD; diagnosed using the Mini-International Neuropsychiatric Interview) with predominantly symptoms of anxiety rather than depression (Covi Anxiety Scale score ⩾9 and Raskin Depression Scale score ⩽7) and Hamilton Rating Scale for Anxiety (HAM-A) score ⩾20. Main exclusions: current Axis I disorders (except simple phobia, somatisation disorder, dysthymia, or depression not otherwise specified); antisocial, borderline, or avoidant personality disorder, recent alcohol or substance use disorder; risk of suicide; ongoing psychodynamic or cognitive-behavioural psychotherapy; or clinically relevant medical comorbidity.

Embedded ImageIntervention:

Pregabalin (400 mg/day or 600 …

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