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Evid Based Mental Health 10:20 doi:10.1136/ebmh.10.1.20
  • Therapeutics

Review: antidepressant use increases the risk of suicidal behaviour and ideation in children


 
 Q Does antidepressant use affect the risk of suicidality in children?

METHODS

GraphicDesign:

Systematic review with meta-analysis.

GraphicData sources:

Submissions to the US Food and Drug Administration (FDA).

GraphicStudy selection and analysis:

All submitted data on placebo-controlled randomised controlled trials (RCTs) of antidepressants in children were included. Only adverse events that occurred during the double blind treatment period, or within one day of its completion were included. Further data searches for potentially suicide related adverse events were requested from drug companies responsible for 23 of the RCTs. Individual patient data on all potentially suicide related adverse events were provided by drug companies. Narrative summaries of each potentially suicide-related adverse event were reviewed by independent blinded assessors who were experts in paediatric suicidality. Events were categorised as suicide attempt, preparation for impending suicidal behaviour, suicidal ideation, self-injury with intent unknown, or injury event with insufficient evidence to determine whether self-inflicted. Data …

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