Statistics from Altmetric.com
Q What is the efficacy of higher doses of venlafaxine extended release compared with standard doses for treating adults with major depressive disorder who do not respond or cannot tolerate selective serotonin reuptake inhibitor therapy?
Randomised controlled trial.
Follow up period:
Twelve weeks (treatment period only).
Twenty two outpatient sites in the USA; time period not stated.
232 adult outpatients (mean age 43) with major depressive disorder (Structured Clinical Interview for DSM-IV) and a score ⩾14 on the 21 item Hamilton Depression Rating scale (HAM-D21) who had not previously taken venlafaxine. Participants had to have a lack of response or inability to tolerate an adequate trial of a selective serotonin reuptake inhibitor (SSRI) during their current depressive episode, within the last 6 months.
Standard dose venlafaxine extended release (ER) (titrated up to 75–150 mg/day) or higher dose venlafaxine ER (titrated up to 375 mg/day) …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.