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Q What are the relative efficacies of the atypical antipsychotics, risperidone and quetiapine, and placebo for people with schizophrenia who have been hospitalised following a recent exacerbation of their illness?
Randomised controlled trial.
Follow up period:
Thirty centres in the USA, India and Romania; time frame not reported.
382 adults (18–64 years) requiring hospitalisation for a recent exacerbation (within the last 4 weeks) of DSM-IV schizophrenia or schizoaffective disorder (confirmed by MINI-Plus), with Clinical Global Impressions of Severity (CGI-S) ⩾5, and with a score of ⩾4 on at least two of the following on total Positive and Negative Syndrome Scale (PANSS): hostility; excitement; tension; uncooperativeness; poor impulse control; total score on these five items of ⩾17. Exclusion criteria: Axis I (except abuse/dependence disorders); Axis II mental retardation/borderline personality disorder; treatment …
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