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Review: aripiprazole for schizophrenia—more high quality research required

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Q Is aripiprazole an effective and tolerable treatment for schizophrenia?

METHODS

Embedded ImageDesign:

Systematic review with meta-analysis.

Embedded ImageData sources:

Cochrane Schizophrenia Group Register (August 2004), hand searches of relevant journals, conference proceedings and reference lists, US Food and Drug Administration website, searches of pharmaceutical industry material and internet resources, and contact with aripiprazole manufacturers.

Embedded ImageStudy selection and analysis:

Randomised controlled trials (RCTs) were included if they compared aripiprazole (any dose) versus either placebo or other antipsychotic drug for the treatment of schizophrenia or schizophrenia-like psychoses. Relative risks (RR), and confidence intervals (CI) were calculated using a conservative intention-to-treat analysis and a random effects model.

Embedded ImageOutcomes:

Primary outcome: relapse. Other outcomes: withdrawal rate, death, adverse effects (headache, anxiety, insomnia, …

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