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Continuing aripiprazole after stabilisation of a manic or mixed episode of bipolar I disorder delays relapse

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 Q How effective is aripiprazole for preventing relapse in people with bipolar I disorder who have recently been stabilised with aripiprazole after experiencing a manic or mixed episode?

METHOD

Embedded ImageDesign:

Randomised controlled trial.

Embedded ImageAllocation:

Unclear.

Embedded ImageBlinding:

Double blind.

Embedded ImageFollow up period:

Twenty six weeks (treatment period).

Embedded ImageSetting:

Seventy six centres, Mexico, US and Argentina; enrolment: March 2000 to June 2003.

Embedded ImagePatients:

161 adults with a manic or mixed episode of DSM-IV bipolar I disorder whose symptoms stabilised after 6–18 weeks open-label 15 or 30 mg/day aripiprazole (lower dose used if higher dose not tolerated; stabilisation defined as total Young Mania Rating Scale score ⩽10 and Montgomery-Asberg Depression Rating Scale score ⩽13 in four consecutive visits over 6 weeks). Exclusions: cognitive disorder, schizophrenia, or schizoaffective disorder; psychotic symptoms explained by substance abuse or another medical disorder; unresponsive to clozapine; psychoactive or substance use disorder; allergy or hypersensitivity to aripiprazole or quinolones; seizure disorder or neuroleptic malignant …

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