Therapeutics
Aripiprazole reduces acute mania compared with haloperidol in bipolar I disorder and causes fewer adverse effects
Vieta E, Bourin M, Sanchez R, et al. Effectiveness of aripiprazole v. haloperidol in acute bipolar mania: double-blind, randomised, comparative 12-week trial. Br J Psychiatry 2005;187:235–42.
Q Is three months of treatment with aripiprazole more effective than haloperidol for people with bipolar disorder having an acute or mixed episode?
Key Words: aripiprazole • haloperidol • bipolar disorder
| The first 150 words of the full text of this article appear below. |
Design:
Multicentre randomised controlled trial.
Allocation:
Unclear.
Blinding:
Double blind.
Follow up period:
Twelve weeks.
Setting:
Seventy six international centres; time period not reported.
Patients:
347 people aged 18–65 years with non-rapid cycling bipolar I disorder (DSM-IV) currently experiencing a recent onset acute or mixed episode, and with Young Mania Rating Score (YMRS) 
20. Exclusions: unresponsiveness to antipsychotics, recent treatment with lithium, divalproate, or long acting antipsychotic, substance misuse, high suicide risk, use of psychotropic medications (except benzodiazepines) or fluoxetine treatment in the prior month, previous enrolment in an aripiprazole trial.
Intervention:
Aripiprazole (15–30 mg daily) or haloperidol (10–15 mg daily) for 12 weeks (after a 1–3 day washout of current medication). Participants who did not tolerate study medication, had a Clinical Global Impression - Bipolar disorder mania severity score of 4, or a Montgomery-Åsberg Depression Rating Scale score 18 at three weeks were removed from the trial.
Outcomes:
Response
Assistant Professor of Psychiatry, Harvard Medical School and Director,
Schizophrenia and Bipolar Disorder Clinic, McLean Hospital, Belmont,
MA USA
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