Therapeutics
Risperidone effectively increases rates of symptomatic remission of acute mania in people with bipolar disorder
Gopal S, Steffens DC, Kramer ML, et al. Symptomatic remission in patients with bipolar mania: results from a double-blind, placebo-controlled trial of risperidone monotherapy. J Clin Psychiatry 2005;66:1016–20.[Medline]
Q Does risperidone increase symptomatic remission of acute mania in people with bipolar disorder?
Key Words: risperidone • mania • bipolar disorder
| The first 150 words of the full text of this article appear below. |
Design:
Randomised controlled trial.
Allocation:
Unclear.
Blinding:
Double blind.
Follow up period:
Three weeks.
Setting:
Eight hospitals, India. Recruitment: March 2001 to December 2001.
Patients:
291 people (aged 18–65 years) with bipolar I disorder (manic or mixed) (DSM-IV; Young Mania Rating Scale (YMRS)). Exclusions: YMRS score <20; no previous history of mania; schizoaffective disorder; rapid cycling bipolar disorder; borderline or antisocial personality disorder; neuroleptic malignant syndrome; substance abuse or dependence; other medical conditions; pregnant or nursing; not taking contraception; or at risk of violent or suicidal behaviour.
Intervention:
The efficacy of risperidone in bipolar disorder was assessed by determining the effects of three weeks of treatment (1–6 mg/day) on symptoms of mania compared with placebo. Initial treatment (
7 days) was in hospital after which participants not considered to be severely ill or at risk of suicide or violence were managed on an outpatient basis.
Outcomes:
Rate of remission of
63 Paschimi Marg, Vasant Vihar, New Delhi 110057, India
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