Prognosis
Review: longer duration of untreated psychosis is associated with worse outcome in people with first episode psychosis
Marshall M, Lewis S, Lockwood A, et al. Association between duration of untreated psychosis and in cohorts of first-episode outcome patients: a systematic review. Arch Gen Psychiatry 2005;62:975–83.
Q Does duration of untreated psychosis affect outcome for people with first episode psychosis?
Key Words: untreated psychosis • first episode psychosis • psychosis
| The first 150 words of the full text of this article appear below. |
Design:
Systematic review with meta-analysis.
Data sources:
CINAHL (January 1982 to May 2004), EMBASE (January 1980 to May 2004), MEDLINE (January 1966 to May 2004), PsychLIT (January 1967 to May 2004), and the Cochrane Schizophrenia Register (2004) plus hand searches of reference lists and reviews.
Study selection and analysis:
Eligible studies were cohort studies of adults (16–60 years old) with first episode psychosis that assessed the association between duration of untreated psychosis and prognosis. Exclusions: follow up <50%; only assessing cognitive functioning or brain structure outcomes; not reporting duration of psychosis. Fisher Z transformation was used in calculating correlation coefficients (r) for all outcomes.
Outcomes:
Primary outcomes: overall symptoms (positive, negative, and neurotic symptoms combined); depression/anxiety; negative and positive symptoms; overall functioning (combination of function scores from measures such as the Global Assessment Scale and Global Assessment of Functioning scale); remission.
Twenty six studies met inclusion criteria (4490
Professor of Psychiatry, University of North Carolina at Chapel Hill,
Chapel Hill, NC, USA
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
LARSEN, T. K., MELLE, I., FRIIS, S., JOA, I., JOHANNESSEN, J. O., OPJORDSMOEN, S., SIMONSEN, E., VAGLUM, P., McGLASHAN, T. H.
(2007). One-year effect of changing duration of untreated psychosis in a single catchment area. Br. J. Psychiatry
191: s128-s132
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Alert me when this article is cited
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
