© 2004 BMJ Publishing Group Ltd., Royal College of Psychiatrists, & British Psychological Society
Therapeutics
Review: high doses of antipsychotic drugs are no more or less effective than medium doses in people with schizophrenia
Davis JM, Chen N. Dose response and dose equivalence of antipsychotics. J Clin Psychopharmacol 2004;24:192–208.[CrossRef][Medline]
Q Which doses of atypical and typical antipsychotic drugs produce a near maximal response with minimal side effects in people with schizophrenia or schizoaffective disorder?
| The first 150 words of the full text of this article appear below. |
Design:
Systematic review with meta-analysis.
Data sources:
MEDLINE, International Pharmaceutical Abstracts, CINAHL, PsycINFO, and the Cochrane Database of Systematic Reviews. Hand searches of reference lists plus data from Food and Drug Administration website, poster presentations, unpublished data from Cochrane reviews, conference abstracts, and manuscripts submitted for publication. Search date: December 2002.
Study selection and analysis:
Double blind, randomised controlled trials of people with schizophrenia or schizoaffective disorder comparing two or more doses of typical or atypical antipsychotics were eligible. Dose response curves were plotted and the median effective dose, defined as 50% of the maximum response (ED50), and the near maximal effective dose range (ED85 to ED95) was established for each drug. Estimated equivalent doses were based on ED50. Meta-analysis determined whether medium and high doses vary in efficacy. The last-observation-carried-forward method and intent-to-treat sample were used for the meta-analysis. The possibility of other biases was explored
Professor of Psychiatry, Yale University School of Medicine, New Haven,
CT, USA
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