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Prognosis
Duration of untreated psychosis significantly associated with positive symptoms one year after treatment
Addington J, Van Mastrigt S, Addington D. Duration of untreated psychosis: impact on 2-year outcome. Psychol Med 2004;34:277–84.[CrossRef][Medline]
Q Does the duration of untreated psychosis influence outcomes one year after initial treatment?
| The first 150 words of the full text of this article appear below. |
Design:
Prospective cohort study.
Setting:
Early Psychosis Program, Calgary, Canada; timeframe not stated.
Population:
200 people (mean age 23 years), out of the 278 people admitted to the Calgary Early Psychosis Program, who completed the one year follow up assessment. Eligible participants had experienced their first episode of psychosis (DSM-IV criteria using Structured Clinical Interview), had significant positive symptoms (rated 
4 on Positive and Negative Syndrome Scale), and had received less than three months prior treatment.
Prognostic factors:
The duration of untreated psychosis was correlated with symptoms and social functioning on entering the programme and after one year. Whether or not the length of untreated psychosis independently predicted symptom outcome and quality of life was tested using linear regression.
Outcomes:
Duration of untreated psychosis (determined at the initial interview by assessing the length of time from the first significant positive symptom until the first effective treatment). Symptoms assessed using the
Emory University School of Medicine, Department of Psychiatry and
Behavioral Sciences, Atlanta, GA, USA
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