© 2003 BMJ Publishing Group Ltd., Royal College of Psychiatrists, & British Psychological Society
Therapeutics
Rofecoxib or naproxen do not slow progression of mild to moderate Alzheimer’s disease
Aisen P, Schafer K, Grundman M, et al.Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial.JAMA 2003;289: 2819–2826
QUESTION: Do rofecoxib or naproxen slow cognitive decline in people with mild to moderate Alzheimer’s disease?
| The first 150 words of the full text of this article appear below. |
Randomised double blind placebo controlled trial.
40 ambulatory treatment centres associated with the Alzheimer’s Disease Cooperative Study, USA; December 1999 to November 2000.
351 people, aged 51 years or more, with mild to moderate Alzheimer’s disease (mini-mental state examination score 13 to 26). Concomitant use of cholinesterase inhibitors, oestrogen, aspirin and vitamin E were permitted. Those allergic to rofecoxib or naproxen, or with peptic ulcer, liver or kidney disease, poorly controlled hypertension, heart failure or bleeding disorder, or who were being treated with other antiinflammatory drugs or treatments for Alzheimer’s disease (other than those listed above), were excluded.
Rofecoxib 25 mg daily or naproxen 220 mg twice daily or placebo for 1 year.
The primary outcome was the change in the cognitive subscale of the Alzheimer’s Disease Assessment Scale (ADAS-Cog) after 1 year. The ADAS-Cog is scored from 0 (no impairment) to 70 (profound impairment). Secondary outcomes included activities of
Professor of Old Age Psychiatry
University of Oxford
Oxford, UK
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Epidemiology
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Dementia, Alzheimer's type
- Psychiatry of old age
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