© 2003 BMJ Publishing Group Ltd., Royal College of Psychiatrists, & British Psychological Society
Therapeutics
Review: cholinesterase inhibitors have a modest effect on neuropsychiatric and functional outcomes in Alzheimer’s disease
Trinh NH, Hoblyn J, Mohanty S, Yaffe K. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA 2003 Jan;280:210–6
QUESTION: How effective are cholinesterase inhibitors for neuropsychiatric and functional outcomes in people with mild to moderate Alzheimer’s disease?
| The first 150 words of the full text of this article appear below. |
Systematic review with meta-analysis.
The authors searched Medline, Dissertations Abstracts, PsychInfo, Biosis, Pubmed, and the Cochrane Controlled Trials Register through December 2001; examined bibliographies of reviews, original research articles, and other articles of interest; and contacted researchers and pharmaceutical companies for additional studies.
Published and unpublished double blind randomised trials in any language were eligible if they focused on outpatients diagnosed with mild to moderate probable Alzheimer’s disease who were treated for at least one month with a cholinesterase inhibitor. 29 parallel group placebo controlled trials were included.
Two reviewers extracted data independently about study methods, sources of bias, and outcomes. Sixteen trials included neuropsychiatric outcomes and 18 included functional measures. Neuropsychiatric outcomes were measured with the Neuropsychiatric Inventory (NPI) and the Alzheimer Disease Assessment Scale, non-cognitive (ADAS-noncog). Data were combined using weighted mean differences. Functional outcomes were measured with activities of daily living and instrumental activities of daily living
Departments of Psychiatry and Neurology
Institute of Psychiatric Research
Indiana University School of Medicine
Indianapolis, Indiana, USA
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Neurology
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Dementia, Alzheimer's type
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Psychiatry of old age
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Epidemiology
- Clinical trials (epidemiology)
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