© 2002 Evidence-Based Mental Health
Therapeutics
Review: selegiline leads to a small short term improvement in cognition and activities of daily living in Alzheimer's disease
Wilcock GK, Birks J, Whitehead A, et al. The effect of selegiline in the treatment of people with Alzheimer's disease: a meta-analysis of published trials. Int J Geriatr Psychiatry 2002 Feb;17:175–83[Medline]
QUESTION: In patients with Alzheimer's disease, does selegiline improve cognitive performance, functional ability, emotional state, and global response?
| The first 150 words of the full text of this article appear below. |
Studies were identified by searching Medline, EMBASE/Excerpta Medica, PyscLIT, the Cochrane Controlled Trials Register, reference lists of retrieved articles, and conference proceedings; and by contacting pharmaceutical companies and authors.
Studies were selected if they were unconfounded, double blind, randomised controlled trials that compared selegiline with placebo in patients with Alzheimer's disease. Studies had to have been reported before the end of 1998; patients had to meet NINCDS-ADRDA or DSM criteria for Alzheimer's disease; and any secondary treatments (eg, physostigmine and lecithin) had to be given to both the selegiline and placebo groups.
Individual patient data were requested. When these data were not provided, summary data were extracted from the published reports for patient characteristics, treatment completion, and outcomes.
14 studies (1073 patients) met the selection criteria, and individual patient data were available for 8 studies (821 patients). 5 studies used a crossover design. Study duration ranged from 3 weeks to
Director of Medical Services, Jewish Home
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