© 2002 Evidence-Based Mental Health
Prognosis
Non-psychotic, non-major affective psychiatric disorders in adolescent boys were associated with greater schizophrenia risk
Weiser M, Reichenberg A, Rabinowitz J, et al. Association between nonpsychotic psychiatric diagnoses in adolescent males and subsequent onset of schizophrenia. Arch Gen Psychiatry 2001 Oct;58:959–64
QUESTION: In adolescent boys with a non-psychotic, non-major affective psychiatric disorder, what is the risk of future schizophrenia?
Population based cohort study with follow up of 4–8 years.
Israel.
9365 boys who had a non-psychotic, non-major affective psychiatric disorder from a cohort of 124 244 boys aged 16–17 years who had a mandatory medical and psychiatric health assessment by the Israeli draft board. Adolescents with affective disorders and those who were admitted to hospital for schizophrenia prior to or within 1 year after the draft board assessment were excluded from the analysis.
The mental health assessment included diagnoses of schizophrenia spectrum personality disorders, adjustment disorder, antisocial personality disorder, impulse control disorder, mental retardation, alcohol and drug abuse, neurosis, and other personality disorders.
The National Psychiatric Hospitalisation Case Registry was used to identify those adolescents screened by the draft board who were later admitted to hospital for schizophrenia.
96 adolescent boys (1.03%) were admitted to hospital 4–8 years later for schizophrenia. The prevalence of non-psychotic non-major affective psychiatric disorders
University of Bristol
Bristol, UK
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