© 2002 Evidence-Based Mental Health
Therapeutics
Paroxetine and sertraline delayed ejaculation in heterosexual men with lifelong rapid ejaculation
Waldinger MD, Zwinderman AH, Olivier B. Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone. J Clin Psychopharmacol 2001 Jun;21:293–7[Medline]
QUESTION: In heterosexual men with lifelong rapid ejaculation, is paroxetine, sertraline, or nefazodone more effective than placebo in delaying ejaculation?
Randomised (allocation concealed*), blinded (clinicians and patients)*, placebo controlled trial with 6 weeks of follow up.
Outpatient Department of Psychiatry and Neurosexology at Leyenburg Hospital, The Netherlands.
48 heterosexual men (mean age 39 y) who had lifelong rapid ejaculation and a stable relationship with a female partner. Rapid ejaculation was defined as an intravaginal ejaculation latency time (IELT) of 
1 minute. Exclusion criteria included erectile dysfunction, alcohol or substance abuse, mental disorders, physical illnesses, and concomitant medications. 83% of patients completed the study.
12 patients were allocated to each of the 4 treatment regimens: paroxetine (20 mg/d), sertraline (50 mg/d), nefazodone (400 mg/d), and placebo in the form of 2 identical capsules per day given in a morning and evening dose for 6 weeks.
IELT defined as the time between the start of vaginal intromission and the start of intravaginal ejaculation measured by partner with stopwatch. Mean IELTs
Imperial College School of Medicine London, UK
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
