© 2002 Evidence-Based Mental Health
Therapeutics
Review: iron treatment does not improve psychomotor development and cognitive function at 30 days in children with iron deficiency anaemia
Logan S, Martins S, Gilbert R. Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia. Cochrane Database Syst Rev 2001;(2):CD001444 (latest version Feb 26 2001).
QUESTION: In children <3 years of age with iron deficiency, does treatment with iron improve psychomotor development and cognitive function?
Studies were identified by searching databases that included the Cochrane Library (2000 Issue 4), Medline (1966 to August 2000), EMBASE/Excerpta Medica (1980 to August 2000), and the Latin American Database (LILACS). Bibliographies of relevant articles were reviewed, key authors in this field were contacted for information on unpublished trials, and forward citation searches on relevant trials were performed within the Science Citation Index.
Randomised controlled trials (RCTs) were selected if they compared iron (oral or intramuscular) with placebo or iron plus vitamin C with placebo plus vitamin C, patients were children <3 years of age, and outcomes included psychomotor development or cognitive function.
2 reviewers independently extracted data on patient characteristics, key components of the intervention, quality of the study, and outcomes.
7 RCTs met the selection criteria: 5 RCTs examined the short term (within 30 days) and 2 trials the longer term effects (after 2 and 4 mo) of
University of British Columbia, Vancouver, British Columbia, Canada
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