© 2002 Evidence-Based Mental Health
Therapeutics
Paroxetine but not imipramine improved depression related outcomes in adolescents with DSM-IV major depression
Keller MB, Ryan ND, Strober M, et al. Efficacy of paroxetine in the treatment of adolescent major depression: a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 2001 Jul;40:762–72[Medline]
QUESTION: In adolescents with major depression, is paroxetine or imipramine more effective than placebo for improving depression related outcomes?
Randomised (unclear allocation concealement*), blinded (patients, clinicians, outcome assessors and statisticians)*, placebo controlled trial with 8 weeks of follow up.
10 centres in the US and 2 in Canada.
275 adolescents (mean age 15 y, 62% girls) who were medically healthy with a current episode of DSM-IV major depression for 
8 weeks. Additional inclusion criteria were a total score of 12 on the Hamilton Depression Rating Scale (HDRS), a score of <60 on the Children's Global Assessment Scale, and a score of 80 on the Peabody Picture Vocabulary Test. Exclusion criteria included a current or lifetime DSM-IV diagnosis of bipolar disorder, schizoaffective disorder, eating disorder, alcohol or substance use disorder, and organic brain disorder. 99% of patients were included in the analysis.
Patients were allocated to 8 weeks of paroxetine (n=93), imipramine (n=95), or placebo (n=87). The paroxetine group received 20 mg/day in the morning for weeks 1–4. Optional
Guy's King's and St Thomas' School of Medicine London, UK
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