© 2002 Evidence-Based Mental Health
Therapeutics
Risperidone was effective for aggression in adolescents with disruptive behaviour disorders and below average intelligence
Buitelaar JK, van der Gaag RJ, Cohen-Kettenis P, et al. A randomized controlled trial of risperidone in the treatment of aggression in hospitalized adolescents with subaverage cognitive abilities. J Clin Psychiatry 2001 Apr;62:239–48[Medline]
QUESTION: In hospitalised young adolescents with disruptive behaviour disorders and below average intelligence, is risperidone effective and safe for treating aggression?
Randomised {allocation concealed*}
, blinded (clinicians, teachers, patients, psychologists, laboratory personnel, and trial monitor};*, placebo controlled trial with 6 weeks of follow up.
2 tertiary referral centres in the Netherlands.
38 patients who were 12–18 years of age (mean age 14 y, 87% boys), had overt aggressive behaviour persisting during hospitalisation (score 
1 on the modified Overt Aggression Scale [OAS-M] rated by nurses); aggressive behaviour not responding to behavioural treatment; clinical indication for study drug; a principal DSM-IV diagnosis of conduct disorder, oppositional defiant disorder or attention deficit hyperactivity disorder; and a Full Scale Intelligence Quotient of 60–90 on the Wechsler Intelligence Scale for Children-Revised. Exclusion criteria included neurological, cardiac, pulmonary, or hepatic diseases; primary mood disorders; schizophrenia or other active psychoses; suicidal tendencies; comorbid substance abuse disorder; pregnancy or inadequate contraception; major change in treatment strategy expected in near future; and inability to discontinue current psychotropic
New York University Medical Center New York, New York, USA
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