© 2001 Evidence-Based Mental Health
A comprehensive coping strategy programme reduced nausea and fatigue after autologous bone marrow transplantation for breast cancer
Gaston-Johansson F, Fall-Dickson JM, Nanda J, et al. The effectiveness of the comprehensive coping strategy program on clinical outcomes in breast cancer autologous bone marrow transplantation. Cancer Nurs 2000 Aug;23:277–85.[Medline]
QUESTION: In women having autologous bone marrow transplantation (ABMT) for breast cancer, does a comprehensive coping strategy programme (CCSP) reduce pain, fatigue, psychological distress, and nausea?
Randomised (unclear allocation concealment*), {blinded (clinicians, outcome assessors, and statisticians)}
*, controlled trial with 7 days of follow up after ABMT.
A comprehensive cancer centre in the eastern US.
110 women who were 
18 years of age (53% were 41–50 y of age); had stage II, III, or IV breast cancer; and were scheduled for ABMT. Follow up was 100%.
Women were allocated to CCSP (n=52) or no CCSP (n=58). CCSP consisted of preparatory information to increase control; cognitive restructuring, including positive coping statements and avoidance of catastrophising; and relaxation with guided imagery. A clinical social worker taught the CCSP intervention 2 weeks before hospital admission for chemotherapy and ABMT. The CCSP group received handouts on methods for reducing pain and psychological distress and increasing control, styles of distorted thinking to avoid, 15 positive coping self statements to use, and methods of relaxation therapy using an audiotape.
Pain (Gaston-Johansson
University Hospital Eppendorf Hamburg, Germany
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