© 2000 Evidence-Based Mental Health
3 year survival rates did not differ between patients with Alzheimer's disease and those with dementia with Lewy bodies
Walker Z, Allen RL, Shergill S, et al. Three years survival in patients with a clinical diagnosis of dementia with Lewy bodies. Int J Geriatr Psychiatry 2000 Mar;15:267–73.[Medline]
QUESTION: In patients with Alzheimer's disease (AD) and in those with dementia with Lewy bodies (DLB), do mortality rates and duration of illness differ?
Inception cohort followed up for 3 years.
An old age psychiatry unit in the UK.
114 patients with a clinical diagnosis of AD using ICD-10 criteria or a diagnosis of DLB using McKeith and Byrne criteria. 8 patients (7%) were lost to follow up.
Case notes of all patients were reviewed to determine the original diagnosis, and the dates of symptoms onset and first presentation to psychiatric services.
Mortality rate and duration of illness were determined by reviewing case notes, hospital files, and general practitioner records.
Of the 106 patients followed, 43 originally had a diagnosis of AD, 32 had DLB, 30 had a diagnosis of vascular dementia, and 1 was diagnosed with alcoholic dementia. At 3 years, 64 patients (60%) had died. More patients died in the vascular dementia group (87%) than in the DLB group (53%) and the AD group (49%) (p<0.003). No difference existed in the mortality
Imperial College, London, UK
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