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Evidence-Based Mental Health 2000;3:57; doi:10.1136/ebmh.3.2.57
Copyright © 2000 by BMJ Publishing Group Ltd, Royal College of Psychiatrists, & British Psychological Society.
Evidence-Based Mental Health 2000; 3:57
© 2000 Evidence-Based Mental Health

Dementia in advanced age led to higher mortality rates and shortened life

Agüero-Torres H, Fratiglioni L, Guo Z, et al. Mortality from dementia in advanced age: a 5-year follow-up study of incident dementia cases. J Clin Epidemiol 1999 Aug;52:737–43.[Medline]

QUESTION: What is the mortality rate and survival time for patients with dementia in advanced age, and does this rate vary by sex and age?

Design

Inception cohort followed up for 5 years.

Setting

Community based study in Stockholm, Sweden.

Patients

127 patients (65% >=85 y of age, 87% women) with clinically definite dementia using DSM-III-R criteria; 80% had Alzheimer's disease (AD), 17% had vascular dementia, and 3% were classified as having other dementias. A comparison group of 790 non-demented people (61% between 77 and 84 y of age, 75% women) were also followed.

Assessment of prognostic factors

At baseline, data on family and personal history were collected and psychological tests were administered. A diagnosis of dementia was made using DSM-III-R criteria.

Main outcome measures

Mortality rate and survival time.

Main results

After 5 years, 70% of patients with dementia had died compared with 35% of those without dementia. After controlling for sociodemographic variables and comorbidity, 14% of all deaths could be attributed to dementia with a risk of death among patients with dementia twice as high as that for non-demented people. The mean survival time was . . . [Full text of this article]

Simon Hatcher, BSc, MBBS, MMedSc

University of Auckland, Auckland, New Zealand,


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