© 2000 Evidence-Based Mental Health
Dementia in advanced age led to higher mortality rates and shortened life
Agüero-Torres H, Fratiglioni L, Guo Z, et al. Mortality from dementia in advanced age: a 5-year follow-up study of incident dementia cases. J Clin Epidemiol 1999 Aug;52:73743.[Medline]
QUESTION: What is the mortality rate and survival time for patients with dementia in advanced age, and does this rate vary by sex and age?
Inception cohort followed up for 5 years.
Community based study in Stockholm, Sweden.
127 patients (65%
85 y of age, 87% women) with clinically definite dementia using DSM-III-R criteria; 80% had Alzheimer's disease (AD), 17% had vascular dementia, and 3% were classified as having other dementias. A comparison group of 790 non-demented people (61% between 77 and 84 y of age, 75% women) were also followed.
At baseline, data on family and personal history were collected and psychological tests were administered. A diagnosis of dementia was made using DSM-III-R criteria.
Mortality rate and survival time.
After 5 years, 70% of patients with dementia had died compared with 35% of those without dementia. After controlling for sociodemographic variables and comorbidity, 14% of all deaths could be attributed to dementia with a risk of death among patients with dementia twice as high as that for non-demented people. The mean survival time was
University of Auckland, Auckland, New Zealand,
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