© 1999 Evidence-Based Mental Health
Current cigarette smoking was associated with a higher risk of Alzheimer's disease
Merchant C, Tang MX, Albert S , et al. The influence of smoking on the risk of Alzheimer's disease.Neurology 1999 Apr 22;52:1408–12
Question Is there an association between cigarette smoking and Alzheimer's disease (AD)?
Cohort analytic study with follow up for a mean of 2 years.
Community based study in northern Manhattan, New York City, USA.
1062 elderly Medicare recipients (mean age 75 y, 69% women) without dementia at start of study.
A structured risk factor questionnaire was developed and used at baseline to determine exposure to putative risk factors related to dementia. 3 sets of questions dealt with smoking history. General health and function, years of formal education, and medical history were determined. A physical, neurological, and neuropsychological examination were also done. APOE genotype was determined for each participant.
Blinded diagnosis of AD using standardised clinical assessments at annual visits.
142 participants were diagnosed with AD during follow up. After adjustment for education and ethnicity and using never smoked as the reference, a previous history of smoking was not associated with AD (table
). Those who were current smokers had an increased risk
Edgeway Community Hospital Brain Injury Unit Middlesex, UK
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