© 1999 Evidence-Based Mental Health
Equivalent response to methylphenidate in children with ADHD plus anxiety and those with ADHD only
Diamond IR, Tannock R, Schachar RJ. Response to methylphenidate in children with ADHD and comorbid anxiety. J Am Acad Chil Adolesc Psychiatry 1999 Apr;38:402–9.
Question Does comorbid anxiety moderate the response to methylphenidate in children with attention deficit hyperactivity disorder (ADHD)?
Randomised, double blind, placebo controlled, trial with 4 months follow up.
An outpatient, referral based, assessment and treatment programme for ADHD in a university clinic at The Hospital for Sick Children, Toronto, Ontario, Canada.
91 children between 6 and 12 years of age (mean age 8 y, 81% boys) with a confirmed diagnosis of ADHD beginning before 7 years of age were included. Exclusion criteria were: attended a full time residential or day treatment programme, received regular medication for a medical problem, had a primary anxiety or affective disorder (ie, the child required treatment for these disorders first), or had a chronic medical condition including a tic disorder or Tourette's syndrome. 38 children had comorbid anxiety disorder.
Children and their families were assigned to 1 of 4 treatment conditions: (1) methylphenidate plus parent training, (2) methylphenidate plus parent support, (3) placebo plus parent training, or (4) placebo plus parent support.
New York State Psychiatric Institute New York, New York, USA
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