OTHER
Therapeutics
Review: statins do not protect against development of dementia
| The first 150 words of the full text of this article appear below. |
Are statins effective for prevention of dementia?
Objective diagnosis of dementia, Alzheimer’s disease or vascular dementia using standardised criteria; or change in Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale-Cognitive or other standardised tests of cognitive performance in patients at risk of Alzheimer’s disease/vascular dementia.
Systematic review.
MEDLINE, EMBASE, The Specialised Register of the Cochrane Dementia and Cognitive Improvement Group, The Cochrane Library, PsycINFO, CINAHL and LILACS (searched from inception to October 2007), in addition to conference proceedings, theses and ongoing trials.
Two reviewers independently selected and appraised double blind, randomised, placebo controlled trials comparing any statin with placebo (administered for a minimum of 12 months) in people with normal cognitive function but of sufficient age to be at risk of Alzheimer’s disease (including those at risk of cerebrovascular disease). Exclusions: direct comparison trials or those without a control group.
Two randomised placebo controlled trials were eligible for inclusion:
Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA
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